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10 Great Chemistry Gift Ideas: A Guide for Science Lovers
Finding the perfect gift for a chemist can be a bit of a challenge. Here’s a list of 10 great gifts to delight the chemist in your life.
the-chemistry-editor
Aug 23, 20243 min read
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Baldwin's Rules: Predicting the Outcome of Ring-Closing Reactions
Baldwin's Rules, introduced by Jack Baldwin in 1976, are guidelines for predicting the favorability of ring-closing reactions.
the-chemistry-editor
Aug 23, 20243 min read
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Measuring Steric Impact: Understanding 'A Values'
How do we compare the steric demand of different substituents? One method is to consider their 'A values', derived from cyclohexane studies.
the-chemistry-editor
Jul 18, 20245 min read
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The Rise of PROTACs in Medicinal Chemistry
PROTACs bring together a target protein and an E3 ligase. The protein is then selectively ubiquitinated and degraded by the proteasome.
the-chemistry-editor
Jul 10, 20243 min read
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Mosher's Esters: A Key Tool in Stereochemical Analysis
Mosher’s acids are chiral derivatizing agents that react with chiral alcohols to form Mosher’s esters and enable stereochemical analysis.
the-chemistry-editor
Jun 28, 20244 min read
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The Chiral Pool: Harnessing Nature's Chirality
The chiral pool refers to a collection of readily available, naturally occurring chiral molecules, such as amino acids, sugars and terpenes.
the-chemistry-editor
Jun 18, 20243 min read
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Ellman’s Sulfinamide Auxiliaries in the Synthesis of Chiral Amines
Ellman's tert-butylsulfinamides were introduced by Jonathan A. Ellman in 1997 as a chiral auxiliary for the synthesis of enantiopure amines.
the-chemistry-editor
Jun 4, 20243 min read
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The Fürst-Plattner Rule: Regioselective Epoxide Opening
The Fürst-Plattner rule allows us to predict the regio- and stereochemical outcome of epoxide-opening reactions on six-membered rings.
the-chemistry-editor
May 20, 20241 min read
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The Staudinger Reaction: Conversion of Azides into Amines
The Staudinger reaction is a useful reaction that involves the reduction of an azide to an amine using triphenylphosphine.
the-chemistry-editor
May 16, 20241 min read
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The Mitsunobu Reaction in Organic Synthesis
The Mitsunobu reaction is a convenient method for the conversion of alcohols into esters, aryl ethers, azides, sulfonamides and sulfides.
the-chemistry-editor
Apr 30, 20242 min read
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Stereoselective Allylation with Allylsilanes: The Hosomi–Sakurai Reaction
Whereas allylations involving allylboron reagents are Type I allylations, the Hosomi–Sakurai reaction is an example of a Type II
the-chemistry-editor
Mar 10, 20243 min read
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The Chemistry of Oxytocin – The "Love Hormone"
Within the intricate web of human emotions and connections, there exists a tiny yet powerful molecule known as oxytocin. Often dubbed the...
the-chemistry-editor
Feb 18, 20242 min read
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COX Inhibitors: The Chemistry of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of medications used to alleviate pain, reduce inflammation and lower fever.
the-chemistry-editor
Feb 17, 20241 min read
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The History of Swern and Related 'Activated DMSO' Oxidations
In 1978, Daniel Swern and Kanji Omura published their paper introducing the Swern Reaction, the most popular 'activated DMSO' oxidation.
the-chemistry-editor
Feb 8, 20246 min read
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Unearthing Clovibactin: A Breakthrough Depsipeptide Antibiotic Defying Drug Resistance
The potent depsipeptide antibiotic clovibactin defies drug resistance. It is sourced from previously uncultivated soil bacteria.
the-chemistry-editor
Jan 9, 20242 min read
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From the Archives: Crouch's 'Selective Monodeprotection of Bis-silyl Ethers'
An indispensable reference guide for planning synthetic pathways that require the strategic use of silyl protecting groups.
the-chemistry-editor
Sep 12, 20232 min read
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From the Archives: Nudelman's Essential NMR Analysis Reference Guide
A tool in the arsenal of nearly every organic chemist, Nudelman's paper has been the go-to guide for NMR analysis for over 25 years.
the-chemistry-editor
Aug 29, 20233 min read
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Heptapeptide Antibiotic with a Twist: The Synthesis of Darobactin A
In the summer of 2022, two syntheses of darobactin A were reported within a week of each other; the first by Sarlah, the second by Baran.
the-chemistry-editor
Aug 17, 20234 min read
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