Baldwin's Rules: Predicting the Outcome of Ring-Closing Reactions
Baldwin's Rules, introduced by Jack Baldwin in 1976, are guidelines for predicting the favorability of ring-closing reactions.
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the-chemistry-editor
Jun 284 min read
Mosher's Esters: A Key Tool in Stereochemical Analysis
Mosher’s acids are chiral derivatizing agents that react with chiral alcohols to form Mosher’s esters and enable stereochemical analysis.
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the-chemistry-editor
Jun 43 min read
Ellman’s Sulfinamide Auxiliaries in the Synthesis of Chiral Amines
Ellman's tert-butylsulfinamides were introduced by Jonathan A. Ellman in 1997 as a chiral auxiliary for the synthesis of enantiopure amines.
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the-chemistry-editor
May 201 min read
The Fürst-Plattner Rule: Regioselective Epoxide Opening
The Fürst-Plattner rule allows us to predict the regio- and stereochemical outcome of epoxide-opening reactions on six-membered rings.
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the-chemistry-editor
May 161 min read
The Staudinger Reaction: Conversion of Azides into Amines
The Staudinger reaction is a useful reaction that involves the reduction of an azide to an amine using triphenylphosphine.
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the-chemistry-editor
Apr 302 min read
The Mitsunobu Reaction in Organic Synthesis
The Mitsunobu reaction is a convenient method for the conversion of alcohols into esters, aryl ethers, azides, sulfonamides and sulfides.
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the-chemistry-editor
Mar 103 min read
Stereoselective Allylation with Allylsilanes: The Hosomi–Sakurai Reaction
Whereas allylations involving allylboron reagents are Type I allylations, the Hosomi–Sakurai reaction is an example of a Type II
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the-chemistry-editor
Feb 182 min read
The Chemistry of Oxytocin – The "Love Hormone"
Within the intricate web of human emotions and connections, there exists a tiny yet powerful molecule known as oxytocin. Often dubbed the...
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the-chemistry-editor
Feb 86 min read
The History of Swern and Related 'Activated DMSO' Oxidations
In 1978, Daniel Swern and Kanji Omura published their paper introducing the Swern Reaction, the most popular 'activated DMSO' oxidation.
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the-chemistry-editor
Sep 12, 20232 min read
From the Archives: Crouch's 'Selective Monodeprotection of Bis-silyl Ethers'
An indispensable reference guide for planning synthetic pathways that require the strategic use of silyl protecting groups.
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the-chemistry-editor
Aug 29, 20233 min read
From the Archives: Nudelman's Essential NMR Analysis Reference Guide
A tool in the arsenal of nearly every organic chemist, Nudelman's paper has been the go-to guide for NMR analysis for over 25 years.
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the-chemistry-editor
Aug 17, 20234 min read
Heptapeptide Antibiotic with a Twist: The Synthesis of Darobactin A
In the summer of 2022, two syntheses of darobactin A were reported within a week of each other; the first by Sarlah, the second by Baran.
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